Script Summary: Hides questions on the home page and main question list which have certain uninteresting tags, unless they also have some interesting tags
Adds a module to the sidebar when viewing the question list on the front page or the questions page, which allows you to specify tags to be ignored.
Tags can be added by typing in the appropriate text input then pressing return or clicking Add, and can be deleted by clicking on the tag links under each heading. Wildcard "*" characters can be used to help squash tag naming variants. Tag changes will take effect immediately and persist thereafter.
Since there can be overlap in things you know nothing about and things you're interested in - you might not use C# often or ever, but you might still be interested in Regex questions, for example - you can also specify "interesting" tags.
Questions which have any of your ignored tags and none of your interesting tags will be hidden when you make tag changes and on page load.
As of March 11th 2011, the script adds a "Show tag details" checkbox to the updated Tags page, which allows you to toggle between an old-style compact view and the new detailed display of tags for easier browsing, persisting your preference.